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Abstract #0382

Fast whole brain MR imaging of dynamic susceptibility contrast changes in the CSF (cDSC MRI)

Di Cao1,2, Ningdong Kang1, Jay J. Pillai1, Xinyuan Miao1,2, Adrian Paez2, Xiang Xu1,2, Jiadi Xu1,2, Xu Li1,2, Qin Qin1,2, Peter C.M. Van Zijl1,2, Peter Barker1, and Jun Hua1,2
1Johns Hopkins University, Baltimore, MD, United States, 2Kennedy Krieger Institute, Baltimore, MD, United States

The circulation of cerebrospinal fluid (CSF) influences various aspects of brain physiology. This study aims to develop and optimize MRI sequences that can detect dynamic signal changes in the CSF after Gd administration with a sub-millimeter spatial resolution, temporal resolution of <10s, and whole brain coverage. Bloch simulations were performed to determine optimal imaging parameters. Simulations were validated with phantom scans. An optimized turbo-spin-echo (TSE) sequence was performed on healthy volunteers on 3T and 7T. In human scans, dynamic signal changes after Gd injection in the CSF were detected at location where cerebral lymphatic vessels were identified in previous studies.

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