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Abstract #0381

Upright vs. Supine MRI: Effects of body position on craniocervical CSF flow

Marco Muccio1, David Chu2, Lawrence Minkoff2, Neeraj Kukarni2, Brianna Damadian2, Raymond Damadian2, and Yulin Ge1
1Department of Radiology, New York University Grossman School of Medicine, New York City, NY, United States, 2FONAR Corporation, Melville, NY, United States

CSF exchange between the spinal cord and the cranium increases in asymptomatic human subjects when body position is shifted from upright to supine. This appears to be caused by an increase in CSF flow during diastole, in the caudo-cranial direction, and systole, in cranio-caudal direction. Extrapolation of the results showed that within a 24 hour timescale, the more time spent in the supine position (asleep) correlated with more CSF exchanged between the spinal cord and the intracranial space. These alterations can therefore play a major role in brain waste clearance, and possibly many neurodegenerative diseases as well as age-related ailments.

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