Cerebrospinal fluid (CSF) flow is essential for brain health, and previous studies have shown that it is driven by systemic physiological factors, such as breathing. Recent work has shown that neural activity is coupled to CSF flow during sleep, but whether this relationship reflects a causal link has not been tested. Here we investigated whether driving neural activity can induce changes in CSF flow. We found that we could induce CSF flow in the human brain during the awake state by manipulating hemodynamics with stimulus-evoked neural activity.
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