Abstract #0402

b-M1-Optimized Waveforms for Improved Stability of Quantitative Intravoxel Incoherent Motion DWI

Gregory Simchick^1,2, Ruiqi Geng^1,2, Yuxin Zhang^1,2, and Diego Hernando^1,2,3

¹Radiology, University of Wisconsin-Madison, Madison, WI, United States, ²Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ³Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States

Multiple studies have demonstrated the potential utility of intravoxel incoherent motion (IVIM) DWI in the evaluation of liver disease. However, IVIM estimates obtained using conventional monopolar diffusion gradient waveforms often suffer from high variability and instability. In this work, Cramer-Rao lower bound (CRLB) optimization was performed to determine the optimal sampling of b-M₁-space based on noise performance. Then, based on this optimized sampling, b-M₁-optimized waveforms were designed and employed in order to obtain IVIM estimates with improved stability in the right lobe of the liver in volunteers in comparison to conventional monopolar waveforms.

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