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Abstract #0403

Resolving the underlying sources of diffusion kurtosis in focal ischemia by Correlation Tensor MRI

Rita Alves1, Rafael Neto Henriques1, Sune Nørhøj Jespersen2,3, and Noam Shemesh1
1Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal, 2Center of Functionally Integrative Neuroscience (CFIN) and MINDLab, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, 3Department of Physics and Astronomy, Aarhus University, Aarhus, Denmark

Correlation Tensor MRI (CTI) has been recently introduced for resolving the underlying sources of diffusional kurtosis. Here, we aimed to resolve the underlying kurtosis sources in ischemic tissue. Ex and in vivo CTI experiments in a mouse model of ischemia revealed enhanced sensitivity and specificity compared to their conventional counterparts. Our results suggest that microscopic kurtosis – associated with restricted diffusion and structural disorder – substantially contributes to the total kurtosis excess likely reflecting excitotoxic properties. Kurtosis associated with diffusion magnitude variance better reflected edema and free water. These first results are promising for elucidating biological factors in ischemia.

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