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Abstract #0418

Multiparametric Renal MRI in Chronic Kidney Disease: Changes in MRI and Clinical Measures Over Two Years

Charlotte E Buchanan1, Rebecca Noble2, Eleanor Cox1, Huda E Mahmoud2, Isma Kazmi2, Benjamin Prestwich1, Nicholas Selby2, Maarten Taal2, and Susan T Francis1
1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2Centre for Kidney Research and Innovation, University of Nottingham, Derby, United Kingdom

We use multi-parametric renal MRI to assess structural and haemodynamic changes in CKD patients and assess these changes after one and two years to investigate the ability of MRI measures to predict and monitor progression of CKD. At baseline, higher renal cortex T1 and a reduction in renal cortex perfusion are associated with subsequent progression of CKD over 2 years suggesting that these MRI parameters may be predictors of progression. Renal cortex T1 and total kidney volume changed more in ‘progressors’ than in ‘stable’ participants over time compared to baseline suggesting these to be useful MRI measures to monitor progression.

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