Abstract #0434

Quantitative neuroimaging biomarkers using 3D UTE MRI and ferumoxytol

Codi Gharagouzloo¹, Praveen Kulkarni², Joshua Leaston¹, Kevin Johnson³, Jonathan Polimeni⁴, Ju Qiao⁵, Misung Han⁶, Peder Larson⁶, and Craig Ferris²

¹Imaginostics, Inc., Cambridge, MA, United States, ²Center for Translational Neuroimaging, Northeastern University, Boston, MA, United States, ³Medical Physics, University of Wisconsin–School of Medicine and Public Health, Madison, WI, United States, ⁴Martinos Center, Massachusetts General Hospital and Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, United States, ⁵Massachusetts General Hospital, Boston, MA, United States, ⁶University of California, San Francisco, San Francisco, CA, United States

New quantitative vascular neuroimaging biomarkers are made possible by the combination of optimized 3D UTE MRI and ferumoxytol for contrast enhancement. Here, we have shown that this method, QUTE-CE MRI, can be used to image both the vascular and perivascular space. The small vessel density biomarker demonstrated sensitivity to hyper-to-normal microvascularization from 8-24 months of age in an ApoE4 genetic knock-in rat model. Disruption in the blood brain barrier was detected in individual animals and groups after even a single mild hit to the head. Finally, feasibility of QUTE-CE MRI is demonstrated on clinical scanners for human imaging.

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