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Abstract #0435

CEST MRI of temporal changes of hematoma in Intracerebral Hemorrhage (ICH) mouse at 3T

Joseph H. C. Lai1, Jiaxin Liu2, Jianpan Huang1, Yang Liu1, Zilin Chen1, Peng Xiao1, Gilberto K. K. Leung2, and Kannie W. Y. Chan1,3,4
1Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, Hong Kong, 2Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong, 3Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4City University of Hong Kong Shenzhen Research Institute, Shenzhen, China

CEST MRI in hematoma could be challenging depending on the involvement of iron. This study examined the feasibility of CEST in monitoring ICH and its progression over two weeks. The AREX data supported that the iron-overloading pathology might not significantly attenuate CEST contrast as demonstrated both in vitro and in vivo at 3T. We observed the most significant decrease in rNOE (37%) and APT (47%) contrast in lesions were on day7 and day3, respectively, when compared to contralateral side. This could indicate neuropathologies related to lipid and amide, which could be valuable for ICH diagnosis and treatment planning at 3T.

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