Abstract #0436

Abnormal Oxidative Metabolism in the Gray Matter of Cuprizone Mouse Model: An in-vivo NIRS-MRI Study

Mada Hashem^1,2,3,4,5, Ying Wu^1,3,4,5, and Jeff F. Dunn^1,2,3,4,5

¹Department of Radiology, University of Calgary, Calgary, AB, Canada, ²Biomedical Engineering Graduate Program, University of Calgary, Calgary, AB, Canada, ³Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, ⁴Experimental Imaging Centre, University of Calgary, Calgary, AB, Canada, ⁵Cumming School of Medicine, University of Calgary, Calgary, AB, Canada

Non-invasive quantitative imaging of cerebral oxygen consumption is crucial to understand the involvement of oxidative metabolism in neurological diseases. We are applying a novel multimodal technique combining near-infrared spectroscopy and high-field MRI to study the mitochondrial status as well as oxygen delivery and consumption in the cortex of the cuprizone mouse model. In this study, multiple physiological parameters controlling oxidative metabolism were investigated in the cuprizone mice exhibiting demyelination. A mitochondrial impairment and a reduced oxygen consumption rate were found in the gray matter of cuprizone mice, emphasizing the association between abnormal oxidative metabolism and the observed demyelination.

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