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Abstract #0436

Abnormal Oxidative Metabolism in the Gray Matter of Cuprizone Mouse Model: An in-vivo NIRS-MRI Study

Mada Hashem1,2,3,4,5, Ying Wu1,3,4,5, and Jeff F. Dunn1,2,3,4,5
1Department of Radiology, University of Calgary, Calgary, AB, Canada, 2Biomedical Engineering Graduate Program, University of Calgary, Calgary, AB, Canada, 3Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, 4Experimental Imaging Centre, University of Calgary, Calgary, AB, Canada, 5Cumming School of Medicine, University of Calgary, Calgary, AB, Canada

Non-invasive quantitative imaging of cerebral oxygen consumption is crucial to understand the involvement of oxidative metabolism in neurological diseases. We are applying a novel multimodal technique combining near-infrared spectroscopy and high-field MRI to study the mitochondrial status as well as oxygen delivery and consumption in the cortex of the cuprizone mouse model. In this study, multiple physiological parameters controlling oxidative metabolism were investigated in the cuprizone mice exhibiting demyelination. A mitochondrial impairment and a reduced oxygen consumption rate were found in the gray matter of cuprizone mice, emphasizing the association between abnormal oxidative metabolism and the observed demyelination.

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