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Abstract #0443

On quantification errors of R2* and PDFF mapping in trabecularized bone marrow induced by the static dephasing regime

Sophia Kronthaler1, Christof Boehm1, Kilian Weiss2, Marcus R. Makowski1, and Dimitrios C. Karampinos1
1Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany, 2Philips Healthcare, Hamburg, Germany

Chemical shift encoding-based (CSE) water-fat separation techniques are becoming more common in the study of bone marrow changes as they allow the simultaneous assessment of tissue fat-fraction and R2*. A typical acquisition strategy in CSE-MRI aims to minimize the first TE to increase SNR. However, the R2* decay in the presence of trabecular bone microstructure is known to be nontrivial due to the occurrence of the static dephasing regime. The present work investigates, with the help of UTE acquisitions, the quantification errors of R2* and PDFF maps in trabecularized bone marrow due to the presence of the static dephasing regime.

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