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Abstract #0460

Respiratory fluctuations in 3D fMRI from inter-shot phase variations can be reduced by low-rank reconstruction of segmented CAIPI sampling

Xi Chen1, Wenchuan Wu1, and Mark Chiew1
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom

Multi-shot 3D EPI is one of the most popular 3D imaging techniques for fMRI, which can provide higher SNR than 2D single-shot EPI. However, the vulnerability to inter-shot signal variations arising from physiological fluctuations, like respiration-related phase variations, has limited the tSNR benefits of 3D multi-shot acquisitions. To improve the temporal stability of 3D multi-shot EPI for fMRI at 7T, we investigated both the optimization of sampling trajectories which show varying vulnerabilities to the inter-shot inconsistencies, and the use of a low-rank annihilating filter constrained reconstruction which can reduce unwanted temporal variance induced by the inter-shot phase inconsistencies.

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