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Abstract #0459

Beyond BOLD: in search of genuine diffusion fMRI contrast in human brain

Wiktor Olszowy1,2 and Ileana O Jelescu1,2
1CIBM Center for Biomedical Imaging, Lausanne, Switzerland, 2Animal Imaging and Technology, EPFL, Lausanne, Switzerland

Diffusion fMRI (dfMRI) is an alternative to BOLD fMRI. Here, we present the first dfMRI study in humans attempting to minimize all sources of BOLD contamination and comparing functional responses at two field strengths, both for task and resting-state fMRI. Our study benefits from unprecedented high spatiotemporal resolution. We observed task-induced water diffusivity decreases in the perfusion-free b-value regime. Furthermore, we found that positive correlations were largely preserved while anti-correlations were suppressed in dfMRI functional connectivity compared to BOLD. We conclude that dfMRI contrast is genuine and distinct from BOLD mechanisms.

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