Velocity-selective ASL (VSASL) accurately depicts cerebral perfusion, even in regions of severely prolonged arterial transit time (ATT). In contrast, spatially-selective ASL, such as pulsed or pseudo-continuous ASL (PCASL), preserves macrovascular signal of blood flowing to these regions. Recent work highlights the importance of using both methods in a complementary way to more completely assess cerebrovascular pathology. In this study, we describe a novel ASL pulse sequence, dubbed VESPA ASL, in which VSASL and PCASL data are simultaneously acquired within a single scan. We further describe a signal model to quantify cerebral blood flow and ATT from these two data sets.
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