Abstract #0474

Faster regional cerebral blood flow increases in infant heteromodal cortex with 2.5mm3 resolution 3D multi-shot, stack-of-spirals pCASL

Minhui Ouyang¹, John Detre², Chenying Zhao^1,3, Samantha Lam¹, J. Christopher Edgar^1,2, and Hao Huang^1,2

¹Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, PA, United States, ²Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, ³Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, United States

During early infancy, rapid increases of regional cerebral blood flow (rCBF) supports the metabolic needs for the dramatic maturation of infant brains. In this study, we delineated the developmental pattern of infant’s rCBF from 0-18months, with an optimized 3D multi-shot, stack-of-spirals pCASL sequence for high-resolution rCBF at isotropic 2.5mm. Significant age-related rCBF increases were found during this period. The rCBF growth rates were inhomogeneous across the cortex, with faster maturation rates in the heteromodal association cortex and slower in unimodal sensorimotor cortices. Cortical regions with more rapid rCBF growth were associated with faster microstructural maturation of adjacent white matter.

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