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Abstract #0475

Spatiotemporal characteristics of longitudinal changes in cerebral blood flow across the adult lifespan

Hualu Han1,2, Zixuan Lin2,3, Melissa Rundle4, Anja Soldan5, Corinne Pettigrew5, Joshua F. Betz6, Kumiko Oishi7, Yang Li2, Binu P. Thomas8, Peiying Liu2, Marilyn Albert5, Denise Park4, and Hanzhang Lu2,3,9
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, 2The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, United States, 5Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 6Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States, 7Center for Imaging Science, Johns Hopkins University, Whiting School of Engineering, Baltimore, MD, United States, 8Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 9F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Characterization of age-related changes in blood supply is important in understanding brain aging. The present work reports longitudinal studies of age-related changes in cerebral blood flow (CBF) in two separate cognitively-healthy cohorts using complementary MRI techniques. We found that CBF decreased with age and the longitudinal rate of decline was faster than that from the cross-sectional data. The rate of CBF reduction was faster in younger than in older individuals, in contrast to the temporal pattern of brain volume atrophy. There were also significant spatial differences and hemispheric asymmetry in CBF decline rates.

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