Abstract #0475

Spatiotemporal characteristics of longitudinal changes in cerebral blood flow across the adult lifespan

Hualu Han^1,2, Zixuan Lin^2,3, Melissa Rundle⁴, Anja Soldan⁵, Corinne Pettigrew⁵, Joshua F. Betz⁶, Kumiko Oishi⁷, Yang Li², Binu P. Thomas⁸, Peiying Liu², Marilyn Albert⁵, Denise Park⁴, and Hanzhang Lu^2,3,9

¹Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, ²The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, United States, ⁵Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁶Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States, ⁷Center for Imaging Science, Johns Hopkins University, Whiting School of Engineering, Baltimore, MD, United States, ⁸Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁹F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Characterization of age-related changes in blood supply is important in understanding brain aging. The present work reports longitudinal studies of age-related changes in cerebral blood flow (CBF) in two separate cognitively-healthy cohorts using complementary MRI techniques. We found that CBF decreased with age and the longitudinal rate of decline was faster than that from the cross-sectional data. The rate of CBF reduction was faster in younger than in older individuals, in contrast to the temporal pattern of brain volume atrophy. There were also significant spatial differences and hemispheric asymmetry in CBF decline rates.

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