Abstract #0483

Differential Changes in Brain Viscoelastic Properties Observed with MR Elastography in MS and NMOSDs

Ling Fang¹, Matthew C. Murphy², Qiuxia Luo¹, Xiaodong Chen³, Linqi Zhang¹, Bingjun He¹, Jun Chen², Jonathan M. Scott², Meng Yin², Kevin J. Glaser², Richard L. Ehman², Wei Qiu³, and Jin Wang¹

¹Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²Department of Radiology, Mayo Clinic, Rochester, MN, United States, ³Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by demyelination, axonal loss and neurodegeneration. Because of overlapping clinical and imaging features, it is a challenge to distinguish MS from Neuromyelitis optica spectrum disorders (NMOSDs) for which the treatment is different. 3D MR Elastography (MRE) is a potential method to evaluate brain tissue damage in autoimmune diseases of the CNS. By measuring the viscoelasticity of the centrum ovale with 3D MRE, we found significantly decreased damping ratio and loss modulus in MS compared with NMOSDs, suggesting possible diagnostic utility for 3D MRE in MS.

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