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Abstract #0483

Differential Changes in Brain Viscoelastic Properties Observed with MR Elastography in MS and NMOSDs

Ling Fang1, Matthew C. Murphy2, Qiuxia Luo1, Xiaodong Chen3, Linqi Zhang1, Bingjun He1, Jun Chen2, Jonathan M. Scott2, Meng Yin2, Kevin J. Glaser2, Richard L. Ehman2, Wei Qiu3, and Jin Wang1
1Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, 2Department of Radiology, Mayo Clinic, Rochester, MN, United States, 3Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by demyelination, axonal loss and neurodegeneration. Because of overlapping clinical and imaging features, it is a challenge to distinguish MS from Neuromyelitis optica spectrum disorders (NMOSDs) for which the treatment is different. 3D MR Elastography (MRE) is a potential method to evaluate brain tissue damage in autoimmune diseases of the CNS. By measuring the viscoelasticity of the centrum ovale with 3D MRE, we found significantly decreased damping ratio and loss modulus in MS compared with NMOSDs, suggesting possible diagnostic utility for 3D MRE in MS.

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