Abstract #0484

Correlations of serum neurofilament with myelin, axonal and volumetric imaging in multiple sclerosis

Jackie Yik^1,2, Pierre Becquart³, Jasmine Gill³, Shannon H. Kolind^1,2,4,5, Virginia Devonshire⁵, Ana-Luiza Sayao⁵, Alice Schabas⁵, Robert Carruthers⁵, Anthony Traboulsee⁵, G.R. Wayne Moore^2,3, David K.B. Li^4,5, Sophie Stukas³, Cheryl Wellington³, Jacqueline A. Quandt³, Irene M. Vavasour^2,4, and Cornelia Laule^1,2,3,4

¹Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ²International Collaboration on Repair Discoveries, Vancouver, BC, Canada, ³Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, ⁴Radiology, University of British Columbia, Vancouver, BC, Canada, ⁵Medicine, University of British Columbia, Vancouver, BC, Canada

Neurofilaments, particularly the light subunit (NfL), have become a biomarker of interest in multiple sclerosis (MS) and can be measured in blood serum after neuronal damage. NfL has been studied in MS prognosis and treatment monitoring, but little is known about the relationship between NfL and advanced quantitative MRI measures. This exploratory study characterizes the relationship between NfL and myelin water fraction and diffusion measures in different brain regions through regression models. We found NfL to correlate with myelin and axonal damage measures in the whole brain and normal appearing white matter but only to myelin water fraction in lesions.

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