Abstract #0485

Disseminated brain pathology detected with high-resolution MRSI correlates with clinical disability in multiple sclerosis

Eva Heckova¹, Alexandra Lipka¹, Assunta Dal-Bianco², Bernhard Strasser¹, Gilbert Hangel^1,3, Paulus Rommer², Petra Hnilicová⁴, Ema Kantorová⁵, Lukas Hingerl¹, Stanislav Motyka¹, Fritz Leutmezer², Stephan Gruber¹, Siegfried Trattnig^1,6, and Wolfgang Bogner¹

¹High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ²Department of Neurology, Medical University of Vienna, Vienna, Austria, ³Department of Neurosurgery, Medical University of Vienna, Vienna, Austria, ⁴Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia, ⁵Clinic of Neurology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia, ⁶Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria

To enhance the detection of diffuse pathological alterations associated with multiple sclerosis, high-resolution MR spectroscopic imaging was performed at 7T, together with clinical MRI, in 68 MS patients with different levels of clinical disability and 20 healthy controls. Increased myo-inositol, a marker of neuroinflammation-induced astrogliosis, was found in white matter regions appearing normal on clinical MRI, even in subgroup of MS patients with no evidence of clinical disability. Myo-inositol/N-acetylaspartate ratio in the NAWM and cortical gray matter correlated with EDSS, suggesting that reactive astrogliosis and axonal injury play important role in the evolution of MS-related disability.

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