Abstract #0492

Relayed nuclear Overhauser effect (rNOE) imaging identifies multiple sclerosis: an initial human study

Jianpan Huang¹, Jiadi Xu^2,3, Joseph H. C. Lai¹, Henry K. F. Mak⁴, Koon Ho Chan⁵, and Kannie W. Y. Chan^1,3,6

¹Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, ³Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China, ⁵Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China, ⁶City University of Hong Kong Shenzhen Research Institute, Shenzhen, China

Multiple sclerosis (MS) is demyelinating disease of the central nervous system (CNS), which affects more than two million people globally. Here we applied our optimized pulsed-CEST MRI method to acquire relayed nuclear Overhauser effect weighted (rNOEw) images for detecting the pathology changes regarding myelin lipid/protein in human brain with neuromyelitis optica (NMO) and MS on clinical 3T scanner. We found that rNOEw signal of MS brains was significantly lower than that of NMO and NC brains. Our proposed rNOEw imaging method has great potential to assist MS diagnosis and specifically identify MS patients from NMO patients.

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