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Abstract #0493

Probing restricted diffusion and water exchange with free gradient waveforms: Addressing the need for a compartment model

Arthur Chakwizira1, Filip Szczepankiewicz2, Linda Knutsson1,3, and Markus Nilsson2
1Department of Medical Radiation Physics, Lund University, Lund, Sweden, 2Department of Diagnostic Radiology, Lund University, Lund, Sweden, 3Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Diffusion MRI can be used to probe restricted diffusion (compartment size) and water exchange (membrane permeability), but their effects on the signal are entangled. This problem can be addressed by the use of free gradient waveforms designed to disentangle the effects. However, a previously presented approach is invalid at high b-values and long diffusion encoding times. We develop a generalised restriction-exchange model that is valid for arbitrary gradient waveform and all relevant b-values and encoding times. The approach eliminates the shortcomings of the previous restriction-exchange framework.

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