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Abstract #0495

Sensitivity of cortical kurtosis measurement to diffusion time in KINSA modeling assessed with Connectome scanner diffusion MRI

Tianjia Zhu1,2, Qiyuan Tian3,4, Susie Huang3,4, and Hao Huang1,5
1Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States, 2Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 3Department of Radiology, Harvard Medical School, Boston, MA, United States, 4Massachusetts General Hospital, Boston, MA, United States, 5Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

Unlike diffusion in the white matter which can be well characterized by Gaussian diffusion, substantial non-Gaussian diffusion occur in the cerebral cortical mantle featured by widespread barriers of both somas and neurites. We have developed a non-Gaussian compartmental model Kurtosis-based Imaging of Neurite and Soma Architecture (KINSA) in previous studies. Here, we demonstrate the sensitivity of cortical kurtosis to diffusion time in KINSA modeling with both simulated data and in-vivo dMRI data from Connectome scanner. The mean kurtosis sensitivity to diffusion time allows for precisely delineating neurite and soma architecture such as neuronal density and soma radius.

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