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Abstract #0496

Inhomogeneous Magnetization Transfer (ihMT): theoretical characterization of T1D-filtering and experimental validation

Andreea Hertanu1,2, Lucas Soustelle1,2, Arnaud Le Troter1,2, Julie Buron1,2,3, Julie Le Priellec3, Victor N. D. Carvalho1,2,4, Myriam Cayre3, Pascale Durbec3, Gopal Varma5, David C. Alsop5, Olivier M. Girard1,2, and Guillaume Duhamel1,2
1Aix Marseille Univ, CNRS, CRMBM, Marseille, France, 2APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, 3Aix Marseille Univ, CNRS, IBDM, Marseille, France, 4Aix Marseille Univ, CNRS, ICR, Marseille, France, 5Division of MR Research, Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States

Inhomogeneous magnetization transfer (ihMT) signal originates from the residual dipolar interactions and is weighted by the associated dipolar relaxation time T1D. The resulting signal can be modulated by filtering the contribution of short T1D components to emphasize the contrast between different structures, or to enhance the specificity for myelin imaging. In this study, the dependency of ihMTR to T1D is investigated theoretically for different T1D-filtering strengths. Experimental WM/GM relative contrasts for the same configurations are put in perspective with theoretical contrasts resulted from single-T1D and bi-T1D biophysical model simulations.

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