Abstract #0496

Inhomogeneous Magnetization Transfer (ihMT): theoretical characterization of T1D-filtering and experimental validation

Andreea Hertanu^1,2, Lucas Soustelle^1,2, Arnaud Le Troter^1,2, Julie Buron^1,2,3, Julie Le Priellec³, Victor N. D. Carvalho^1,2,4, Myriam Cayre³, Pascale Durbec³, Gopal Varma⁵, David C. Alsop⁵, Olivier M. Girard^1,2, and Guillaume Duhamel^1,2

¹Aix Marseille Univ, CNRS, CRMBM, Marseille, France, ²APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, ³Aix Marseille Univ, CNRS, IBDM, Marseille, France, ⁴Aix Marseille Univ, CNRS, ICR, Marseille, France, ⁵Division of MR Research, Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States

Inhomogeneous magnetization transfer (ihMT) signal originates from the residual dipolar interactions and is weighted by the associated dipolar relaxation time T_1D. The resulting signal can be modulated by filtering the contribution of short T_1D components to emphasize the contrast between different structures, or to enhance the specificity for myelin imaging. In this study, the dependency of ihMTR to T_1D is investigated theoretically for different T_1D-filtering strengths. Experimental WM/GM relative contrasts for the same configurations are put in perspective with theoretical contrasts resulted from single-T_1D and bi-T_1D biophysical model simulations.

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