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Abstract #0503

Rapid Physiological Dynamics Measured by Real-Time MRI at Up to 100Hz: MR Kinematography

Dan Zhu1, Tricia Steinberg2, Robert G. Weiss2, Dirk Voit3, Jens Frahm3, and Paul A. Bottomley4
1Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, 2The Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, United States, 3Biomedizinische NMR, Max-Planck-Institut fur biophysikalische Chemie, Gottingen, Germany, 4The Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, MD, United States

The advent of high-speed real-time (RT) MRI permits monitoring of physiological function at unprecedented frame-rates. Here, physiological dynamics at 25-100 frames-per-second are explored using temporal domain Fourier transform (FT) and principal component analysis (PCA). RT cerebral, cardiac and pharyngeal datasets are acquired with continuous radial encoding and nonlinear inverse reconstruction implemented in graphics processing units. FT detects spectral patterns in pharyngeal images acquired during speaking. FT and PCA reflect components associated with breathing and cardiac functions in the brain while decomposition and synthesis in the time-domain can pinpoint cardiac wall motion abnormalities in patients with heart disease.

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