The complex relationship between brain’ structural connectivity (SC) and functional connectivity (FC) has not yet been fully quantified. Previous studies have shown that an increased SC-FC coupling is associated with worse cognitive performance and higher disability in people with multiple sclerosis (pwMS). However, no study to date investigated the association of regional SC-FC coupling with disability in MS. We showed that the SC-FC coupling performed a high prediction performance in classifying pwMS by impairment level. Damage to SC, particularly in the right parsorbitalis, thalamus, and parahippocampal and left superior parietal is a hallmark of disability in MS.
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