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Abstract #0502

Predicting disability from structural and functional coupling in multiple sclerosis

Ceren Tozlu1, Keith Jamison1, Susan Gauthier1,2,3, and Amy Kuceyeski1
1Department of Radiology, Weill Cornell Medicine, New York, NY, United States, 2Judith Jaffe Multiple Sclerosis Center, Weill Cornell Medicine, New York, NY, United States, 3Department of Neurology, Weill Cornell Medicine, New York, NY, United States

The complex relationship between brain’ structural connectivity (SC) and functional connectivity (FC) has not yet been fully quantified. Previous studies have shown that an increased SC-FC coupling is associated with worse cognitive performance and higher disability in people with multiple sclerosis (pwMS). However, no study to date investigated the association of regional SC-FC coupling with disability in MS. We showed that the SC-FC coupling performed a high prediction performance in classifying pwMS by impairment level. Damage to SC, particularly in the right parsorbitalis, thalamus, and parahippocampal and left superior parietal is a hallmark of disability in MS.

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