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Abstract #0514

Characterize laminar-specific interhemispheric functional coherence in resting-state fMRI using bilateral line-scanning fMRI (BiLS) 

Sangcheon Choi1,2, Yi Chen1, Hang Zeng1,2, and Xin Yu1,3
1Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 2Graduate Training Centre of Neuroscience, Tuebingen, Germany, 3MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, United States

We developed a bilateral line-scanning fMRI method to investigate interhemispheric slow fluctuations (< 0.1 Hz) with laminar specificity in resting-state fMRI in anesthetized rats. Based on the coherence analysis, two distinct slow fluctuation features in symmetric cortices were identified: ultra-slow fluctuation (0.01-0.02 Hz) was synchronized across all cortical laminae, and Layer 2/3 specific slow fluctuations (0.08-0.1 Hz). In contrast to the ultra-slow fluctuation related to global brain state changes, the Layer 2/3 specific slow fluctuation is more likely associated with intrinsic neuronal correlation driven by the callosal projection.

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