Abstract #0526

Measures of bone water and porosity are associated with whole-bone stiffness and mineral density in the human femur

Brandon Clinton Jones^1,2, Hyunyeol Lee¹, Shaowei Jia^1,3, Anna Feng¹, Snehal S Shetye⁴, Hee Kwon Song¹, Felix Werner Wehrli¹, and Chamith Sudesh Rajapakse^1,4

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, ³Biomedical Science and Medical Engineering, Beihang University, Beijing, China, ⁴Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, United States

UTE measures of cortical bone water were evaluated in 15 cadaveric proximal femora. Pore water content, total water content, and porosity index were all negatively associated with whole-bone stiffness obtained in a sideways fall loading configuration and with volumetric bone mineral density. In contrast, bound water content was not found to be related to stiffness or mineral density. This data suggest that bone water measures may provide useful information on cortical bone mechanical competence.

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