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Abstract #0539

Twelve-Year Microstructural Changes in The Deep Gray Nuclei in Parkinson’s Disease: A Serial Diffusion Tensor Imaging Study

Yao-Chia Shih1,2, Qi Rong Leon Ooi3, Septian Hartono2,3, Thomas Welton2,3, Hui-Hua Li2,4, John Carson Allen2, Eng King Tan2,3, and Ling Ling Chan1,2
1Department of Diagnostic Radiology, Singapore General Hospital, Singapore, Singapore, 2Duke-NUS Medical School, Singapore, Singapore, 3Department of Neurology, National Neuroscience Institute (Outram-campus), Singapore, Singapore, 4Health Services Research Unit, Singapore General Hospital, Singapore, Singapore

Diffusion tensor imaging (DTI) characterizes microstructural changes in the basal ganglia in relation to idiopathic Parkinson's disease (PD). However, inconsistent results due to short-interval longitudinal studies with heterogeneous neuropathology across PD stages have been reported. We elucidated microstructural changes in the deep gray nuclei throughout the disease course in a large, prospective, three time-point case-control DTI study in PD over twelve years, with six-year interval gaps. Increased mean striatal diffusivity reflected progressive neurodegeneration, whereas factional anisotropy changes suggested effects of abnormal iron accumulation followed by neuronal loss in the putamen and thalamus as the disease progresses into the late stages.

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