Diffusion tensor imaging (DTI) characterizes microstructural changes in the basal ganglia in relation to idiopathic Parkinson's disease (PD). However, inconsistent results due to short-interval longitudinal studies with heterogeneous neuropathology across PD stages have been reported. We elucidated microstructural changes in the deep gray nuclei throughout the disease course in a large, prospective, three time-point case-control DTI study in PD over twelve years, with six-year interval gaps. Increased mean striatal diffusivity reflected progressive neurodegeneration, whereas factional anisotropy changes suggested effects of abnormal iron accumulation followed by neuronal loss in the putamen and thalamus as the disease progresses into the late stages.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords