Abstract #0540

Characterizing white matter microstructural alterations in de novo Parkinson's disease using diffusion MRI

Yiming Xiao^1,2, Terry M Peters^3,4,5, and Ali R Khan^3,4,5,6

¹PERFORM Centre, Concordia University, Montreal, QC, Canada, ²Computer Science and Software Engineering, Concordia University, Montreal, QC, Canada, ³Robarts Research Institute, Western University, London, ON, Canada, ⁴Department of Medical Biophysics, Western University, London, ON, Canada, ⁵School of Biomedical Engineering, Western University, London, ON, Canada, ⁶The Brain and Mind Institute, Western University, Lonon, ON, Canada

Understanding microstructural alterations in white matter can be instrumental in revealing pathogenesis and devising effective plans to treat Parkinson’s disease (PD). Diffusion MRI can be used to characterize the status of white matter integrity. With voxel-based analysis using DTI measures and fixel-based analysis (FBA), we demonstrated for the first time strengthened and weakened white matter integrity, which is subject to laterality of motor symptoms in de novo Parkinson’s disease. The findings suggest that the disease gives rise to both functional degeneration and the creation of compensatory networks.

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