Meeting Banner
Abstract #0542

Microstructure of grey matter nuclei in early Parkinson’s disease: longitudinal study using diffusion kurtosis imaging

Thomas Welton1,2, Septian Hartono3, Yao-Chia Shih3, Samuel Y-E Ng1, Nicole S Y Chia1, Weiling Lee3, Say Lee Chong3, Eng-King Tan1,2,3, Ling-Ling Chan1,2,3, and Louis CS Tan1,2
1National Neuroscience Institute, Singapore, Singapore, 2Duke-NUS Medical School, Singapore, Singapore, 3Singapore General Hospital, Singapore, Singapore

We show that the diffusion kurtosis characteristics of grey matter nuclei in early Parkinson's disease were abnormal and that this abnormality was maintained over two years. Furthermore, elevated mean kurtosis was associated with worsening motor function. This supports the use of diffusion kurtosis imaging to characterise tissue microstructure and potentially monitor disease progression even in early Parkinson's disease.

This abstract and the presentation materials are available to members only; a login is required.

Join Here