Abstract #0542

Microstructure of grey matter nuclei in early Parkinson’s disease: longitudinal study using diffusion kurtosis imaging

Thomas Welton^1,2, Septian Hartono³, Yao-Chia Shih³, Samuel Y-E Ng¹, Nicole S Y Chia¹, Weiling Lee³, Say Lee Chong³, Eng-King Tan^1,2,3, Ling-Ling Chan^1,2,3, and Louis CS Tan^1,2

¹National Neuroscience Institute, Singapore, Singapore, ²Duke-NUS Medical School, Singapore, Singapore, ³Singapore General Hospital, Singapore, Singapore

We show that the diffusion kurtosis characteristics of grey matter nuclei in early Parkinson's disease were abnormal and that this abnormality was maintained over two years. Furthermore, elevated mean kurtosis was associated with worsening motor function. This supports the use of diffusion kurtosis imaging to characterise tissue microstructure and potentially monitor disease progression even in early Parkinson's disease.

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