Magnetic resonance-guided focused ultrasound (MRgFUS) is a non-invasive tremor therapy associated with Parkinson disease (PD). Conventional fractional anisotropy analysis might neglect pre- and postoperative microanatomic changes due to low spatial resolution. Finer brain structural depictions could be provided using track density imaging (TDI), a super-resolution reconstruction method. This study conducted TDI on seven patients with PD before and 1-month after MRgFUS and found that tract density values were significantly decreased postoperatively in the genu of the corpus callosum and left globus pallidus. TDI could be a valuable tool for detecting microstructural changes after MRgFUS therapy.