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Abstract #0543

Tract Density Imaging in Patients with Parkinson’s Disease Before and After Magnetic Resonance-guided Focused Ultrasound

Yu Shen1, Xianchang Zhang2, Yan Bai1, Rui Zhang1, Rushi Chen1, Wei Wei1, Menghuan Zhang1, and Meiyun Wang1
1Department of Medical Imaging, Henan Provincial People’s Hospital & Zhengzhou University, Zhengzhou, China, 2MR Collaboration, Siemens Healthcare Ltd. Beijing China, Beijing, China

Magnetic resonance-guided focused ultrasound (MRgFUS) is a non-invasive tremor therapy associated with Parkinson disease (PD). Conventional fractional anisotropy analysis might neglect pre- and postoperative microanatomic changes due to low spatial resolution. Finer brain structural depictions could be provided using track density imaging (TDI), a super-resolution reconstruction method. This study conducted TDI on seven patients with PD before and 1-month after MRgFUS and found that tract density values were significantly decreased postoperatively in the genu of the corpus callosum and left globus pallidus. TDI could be a valuable tool for detecting microstructural changes after MRgFUS therapy.

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