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Abstract #0544

Investigating Spatiotemporal Changes in Dopamine, Neuromelanin and Iron in the Nigrostriatal System in Parkinson's Disease

Emma Biondetti1,2,3, Mathieu D. Santin1,2, Romain Valabrègue1,2, Graziella Mangone1,4, Rahul Gaurav1,2,3, Nadya Pyatigorskaya1,3,5, Matthew Hutchison6, Lydia Yahia-Cherif1,2, Nicolas Villain1,7, Marie-Odile Habert8, Isabelle Arnulf1,3,9, Smaranda Leu-Semenescu9, Pauline Dodet9, Jean-Christophe Corvol1,4,7, Marie Vidailhet1,3,7, and Stéphane Lehéricy1,2,3,5
1Institut du Cerveau – ICM, INSERM U 1127, CNRS UMR 7225, Sorbonne Université, Paris, France, 2ICM, Centre de NeuroImagerie de Recherche – CENIR, Paris, France, 3ICM, Team “Movement Investigations and Therapeutics” (MOV’IT), Paris, France, 4National Institute of Health and Medical Research - INSERM, Clinical Investigation Centre, Pitié-Salpêtrière Hospital, Paris, France, 5Department of Neuroradiology, Pitié-Salpêtrière Hospital, AP-HP, Paris, France, 6Biogen Inc., Cambridge, MA, United States, 7Department of Neurology, Pitié-Salpêtrière Hospital, AP-HP, Paris, France, 8Department of Nuclear Medicine, Pitié-Salpêtrière Hospital, AP-HP, Paris, France, 9National Reference Center for Rare Hypersomnias, Pitié-Salpêtrière Hospital, AP-HP, Paris, France

Parkinson's disease (PD) and idiopathic rapid eye movement sleep behaviour disorder (iRBD, a prodromal condition of Parkinsonism) are characterised by progressive striatal dopaminergic denervation, loss of neuromelanin-containing neurons and increased iron deposition in the substantia nigra. Here, we evaluated neurodegeneration-induced changes in the nigrostriatal system of PD and iRBD patients using longitudinal SPECT and MR imaging compared to healthy control subjects. We showed that dopamine, neuromelanin and iron changes followed similar spatiotemporal gradients of neurodegeneration, and we assessed the temporal onset and ordering of such changes.

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