Abstract #0544

Investigating Spatiotemporal Changes in Dopamine, Neuromelanin and Iron in the Nigrostriatal System in Parkinson's Disease

Emma Biondetti^1,2,3, Mathieu D. Santin^1,2, Romain Valabrègue^1,2, Graziella Mangone^1,4, Rahul Gaurav^1,2,3, Nadya Pyatigorskaya^1,3,5, Matthew Hutchison⁶, Lydia Yahia-Cherif^1,2, Nicolas Villain^1,7, Marie-Odile Habert⁸, Isabelle Arnulf^1,3,9, Smaranda Leu-Semenescu⁹, Pauline Dodet⁹, Jean-Christophe Corvol^1,4,7, Marie Vidailhet^1,3,7, and Stéphane Lehéricy^1,2,3,5

¹Institut du Cerveau – ICM, INSERM U 1127, CNRS UMR 7225, Sorbonne Université, Paris, France, ²ICM, Centre de NeuroImagerie de Recherche – CENIR, Paris, France, ³ICM, Team “Movement Investigations and Therapeutics” (MOV’IT), Paris, France, ⁴National Institute of Health and Medical Research - INSERM, Clinical Investigation Centre, Pitié-Salpêtrière Hospital, Paris, France, ⁵Department of Neuroradiology, Pitié-Salpêtrière Hospital, AP-HP, Paris, France, ⁶Biogen Inc., Cambridge, MA, United States, ⁷Department of Neurology, Pitié-Salpêtrière Hospital, AP-HP, Paris, France, ⁸Department of Nuclear Medicine, Pitié-Salpêtrière Hospital, AP-HP, Paris, France, ⁹National Reference Center for Rare Hypersomnias, Pitié-Salpêtrière Hospital, AP-HP, Paris, France

Parkinson's disease (PD) and idiopathic rapid eye movement sleep behaviour disorder (iRBD, a prodromal condition of Parkinsonism) are characterised by progressive striatal dopaminergic denervation, loss of neuromelanin-containing neurons and increased iron deposition in the substantia nigra. Here, we evaluated neurodegeneration-induced changes in the nigrostriatal system of PD and iRBD patients using longitudinal SPECT and MR imaging compared to healthy control subjects. We showed that dopamine, neuromelanin and iron changes followed similar spatiotemporal gradients of neurodegeneration, and we assessed the temporal onset and ordering of such changes.

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