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Abstract #0549

Multi-parametric R2’ Measurement of Brain Oxygen Extraction Fraction: Reproducibility and Application in Moyamoya Disease

Matthew Kim1, Denise Zhong1, Moss Y Zhao2, David Y.T Chen3, David D Shin4, Greg Zaharchuk2, and Audrey P. Fan1,5
1Department of Biomedical Engineering, University of California, Davis, Davis, CA, United States, 2Department of Radiology, Stanford University, Stanford, CA, United States, 3Department of Medical Imaging, Taipei Medical University-Shuan-Ho Hospital, New Taipei City, Taiwan, 4General Electric Healthcare, San Ramon, CA, United States, 5Department of Neurology, University of California Davis, Davis, CA, United States

We quantified R2’ as a biomarker of brain oxygen extraction fraction (OEF) using a multi-parametric approach, based on multi-echo gradient echo (R2*) and fast spin echo scans (R2). Healthy volunteers received repeat scans after 1-2 weeks and the coefficient of variation of R2’ was low (4.4-8.3% in vascular territories), indicating good R2’ scan-rescan reproducibility. R2’ was also inversely correlated with PET scans of cerebral blood flow in healthy controls, as expected. In 14 Moyamoya patients, elevated R2’ (indicating abnormal, high OEF) was observed both in brain regions with and without artery stenosis, and provided complementary information to cerebral perfusion.

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