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Abstract #0553

Fast and repeatable multi-parametric mapping using 3D Echo-Planar Time-resolved Imaging (3D-EPTI) 

Fuyixue Wang1,2, Zijing Dong1,3, Timothy G. Reese1, Lawrence L. Wald1,2, and Kawin Setsompop4,5
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Harvard-MIT Health Sciences and Technology, MIT, Cambridge, MA, United States, 3Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA, United States, 4Department of Radiology, Stanford University, Stanford, CA, United States, 5Department of Electrical Engineering, Stanford University, Stanford, CA, United States

3D-EPTI is a recent multi-parametric mapping technique capable of rapid T1,T2,and T2* quantification. In this work, we characterize the repeatability of two optimized 3D-EPTI whole-brain protocols at 1-mm and 0.7-mm isotropic resolutions (3- and 9-minutes), suitable for a range of clinical and neuroscientific applications. Scan-rescan across 5 subjects shows low intra- and inter-subject variabilities in the derived quantitative-metrics across 165 brain-regions using automatic FreeSurfer segmentation. High-repeatability of quantitative measures across cortical depths was demonstrated using the 0.7-mm protocol, indicating its potential for robust-and-repeatable cortical myeloarchitecture investigation. Lastly, synthetic 3D-EPTI images were demonstrated to be in high-agreement with clinical contrast-weighted images.

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