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Abstract #0556

Quantifying Brain Iron Deposition in patients with Parkinson’s Disease Using MRI-R2*: A new specific approach developed from a multicenter study

Laila khedher1, Jean Marie Bonny2, Ana Marques3, Marie Vidailhet4, Frédéric Torny5, Luc Defebvre6, Stéphane Thobois7, Elena Moro8, Philippe Remy9, Christian Geny10, Wassilios Meissner11, Solène Frismand12, Anne Doe de Maindreville13, Jean-Luc Houeto14, Olivier Rascol15, and Franck Durif1,3
1University Clermont Auvergne, Clermont Ferrand, France, 2INRA, UR370 Qualité des Produits Animaux, Saint Genès Champanelle, France, 3CHU Clermont Ferrand, Clermont Ferrand, France, 4Fédération des maladies du système nerveux GH La Pitié Salpêtrière, Paris, France, 5CHU Dupuytren, Service de Neurologie, Limoges, France, 6Hopital Roger Salengro, Service de Neurologie et Pathologie du Mouvement, Lille, France, 7Hopital Pierre Wertheimer, Neurologie C, Lyon, France, 8CHU de Grenoble, Service de Neurologie, Grenoble, France, 9Hopital Henri Mondor, Service de Neurologie, Creteil, France, 10CHRU Montpellier, Service de Neurologie, Montpellier, France, 11CHU Bordeaux, Service de Neurologie, Bordeaux, France, 12Hopital Central-CHU Nancy, Service de Neurologie, Nancy, France, 13Pole Neurologie-Gériatrie, Reims, France, 14CHU de Poitiers, Poitiers, France, 15Centre d’Investigation Clinique CIC 1436, CHU PURPAN-Place du Dr Baylac, Hopital Pierre Paul Riquet, Toulouse, France

Several postmortem studies have shown an accumulation of iron in the substantia nigra (SN) in Parkinson’s disease (PD). The iron concentration can be estimated by MRI via the MRI-R2* mapping. 1, 2 In order to assess the changes in R2* occurring in PD patients compared to healthy controls, a multicenter transversal prospective study was carried out in a large cohort of PD patients (n = 98) going from the early to the late stage of the disease and matched controls (n = 66).

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