Abstract #0556

Quantifying Brain Iron Deposition in patients with Parkinson’s Disease Using MRI-R2*: A new specific approach developed from a multicenter study

Laila khedher¹, Jean Marie Bonny², Ana Marques³, Marie Vidailhet⁴, Frédéric Torny⁵, Luc Defebvre⁶, Stéphane Thobois⁷, Elena Moro⁸, Philippe Remy⁹, Christian Geny¹⁰, Wassilios Meissner¹¹, Solène Frismand¹², Anne Doe de Maindreville¹³, Jean-Luc Houeto¹⁴, Olivier Rascol¹⁵, and Franck Durif^1,3

¹University Clermont Auvergne, Clermont Ferrand, France, ²INRA, UR370 Qualité des Produits Animaux, Saint Genès Champanelle, France, ³CHU Clermont Ferrand, Clermont Ferrand, France, ⁴Fédération des maladies du système nerveux GH La Pitié Salpêtrière, Paris, France, ⁵CHU Dupuytren, Service de Neurologie, Limoges, France, ⁶Hopital Roger Salengro, Service de Neurologie et Pathologie du Mouvement, Lille, France, ⁷Hopital Pierre Wertheimer, Neurologie C, Lyon, France, ⁸CHU de Grenoble, Service de Neurologie, Grenoble, France, ⁹Hopital Henri Mondor, Service de Neurologie, Creteil, France, ¹⁰CHRU Montpellier, Service de Neurologie, Montpellier, France, ¹¹CHU Bordeaux, Service de Neurologie, Bordeaux, France, ¹²Hopital Central-CHU Nancy, Service de Neurologie, Nancy, France, ¹³Pole Neurologie-Gériatrie, Reims, France, ¹⁴CHU de Poitiers, Poitiers, France, ¹⁵Centre d’Investigation Clinique CIC 1436, CHU PURPAN-Place du Dr Baylac, Hopital Pierre Paul Riquet, Toulouse, France

Several postmortem studies have shown an accumulation of iron in the substantia nigra (SN) in Parkinson’s disease (PD). The iron concentration can be estimated by MRI via the MRI-R2* mapping. 1, 2 In order to assess the changes in R2* occurring in PD patients compared to healthy controls, a multicenter transversal prospective study was carried out in a large cohort of PD patients (n = 98) going from the early to the late stage of the disease and matched controls (n = 66).

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