Fast T1 mapping methods based on subspace-constrained reconstructions of jointly sparsed-sample domains, are proposed and shown to efficiently deliver maps with either multiple T1 contrasts or T1 values with ≈ 50-100× accelerations. Both single-shot and multi-shot implementations were developed, incorporating random-sampling inversion recovery (IR) as well as variable-TR multi-shot gradient echo (GRE) and spatiotemporally encoded (SPEN) sequences. In vivo human brain scans confirmed the efficiency of this method. Preclinical scans on kidneys and on tumor-implanted animals subject to dynamic contrast-enhanced T1 mapping, also demonstrate the proposed method's advantages for functional and pathological diagnoses.
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