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Abstract #0557

Fast T1 mapping and weighting MRI in preclinical and clinical settings using subspace-constrained joint-domains reconstructions

Lingceng Ma1,2, Qingjia Bao1, Ricardo P. Martinho1, Zhong Chen2, and Lucio Frydman1
1Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, Israel, 2Department of Electronic Science, Xiamen University, Xiamen, China

Fast T1 mapping methods based on subspace-constrained reconstructions of jointly sparsed-sample domains, are proposed and shown to efficiently deliver maps with either multiple T1 contrasts or T1 values with ≈ 50-100× accelerations. Both single-shot and multi-shot implementations were developed, incorporating random-sampling inversion recovery (IR) as well as variable-TR multi-shot gradient echo (GRE) and spatiotemporally encoded (SPEN) sequences. In vivo human brain scans confirmed the efficiency of this method. Preclinical scans on kidneys and on tumor-implanted animals subject to dynamic contrast-enhanced T1 mapping, also demonstrate the proposed method's advantages for functional and pathological diagnoses.

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