Meeting Banner
Abstract #0558

Quantitative T1 mapping by multi-slice multi-shot inversion recovery EPI: correction of fat suppression MT effects.

Rosa Sanchez Panchuelo1, Olivier Mougin1, Robert Turner1,2, and Susan Francis1,3
1Sir Peter Mansfield Imaging Centre, UP, University of Nottingham, Nottingham, United Kingdom, 2Max Planck Institute for Human Cognitive and Brain Sciences, Leibzig, Germany, 3NIHR Nottingham Biomedical Research, University of Nottingham, Nottingham, United Kingdom

Multi-slice inversion–recovery EPI (MS-IR-EPI) combined with slice order shifting across multiple acquisitions can provide a fast method for high spatial resolution T1 mapping. However, magnetization transfer (MT) effects of spectrally-selective fat-suppression pulses used in in-vivo imaging shorten measured T1-values. Here we model the effect of fat-suppression pulses on measured T1 and use this model to remove the MT contribution, improving the accuracy of T1 quantification. MT-corrected high spatial resolution T1 maps of the human brain generated with MS-IR-EPI at 7T are compared with those generated with the widely implemented MP2RAGE sequence and standard single slice IR-EPI.

This abstract and the presentation materials are available to members only; a login is required.

Join Here