Abstract #0558

Quantitative T1 mapping by multi-slice multi-shot inversion recovery EPI: correction of fat suppression MT effects.

Rosa Sanchez Panchuelo¹, Olivier Mougin¹, Robert Turner^1,2, and Susan Francis^1,3

¹Sir Peter Mansfield Imaging Centre, UP, University of Nottingham, Nottingham, United Kingdom, ²Max Planck Institute for Human Cognitive and Brain Sciences, Leibzig, Germany, ³NIHR Nottingham Biomedical Research, University of Nottingham, Nottingham, United Kingdom

Multi-slice inversion–recovery EPI (MS-IR-EPI) combined with slice order shifting across multiple acquisitions can provide a fast method for high spatial resolution T₁ mapping. However, magnetization transfer (MT) effects of spectrally-selective fat-suppression pulses used in in-vivo imaging shorten measured T₁-values. Here we model the effect of fat-suppression pulses on measured T₁ and use this model to remove the MT contribution, improving the accuracy of T₁quantification. MT-corrected high spatial resolution T₁maps of the human brain generated with MS-IR-EPI at 7T are compared with those generated with the widely implemented MP2RAGE sequence and standard single slice IR-EPI.

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