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Abstract #0574

Evolutionarily conserved fMRI network dynamics in the human, macaque and mouse brain

Daniel Gutierrez-Barragan1, Stefano Panzeri2, Ting Xu3, and Alessandro Gozzi1
1Functional Neuroimaging Laboratory,, Istituto Italiano di Tecnologia, CNCS, Rovereto, Italy, 2Neural Computation Laboratory, Istituto Italiano di Tecnologia, CNCS, Rovereto, Italy, 3Center for the Developing Brain, Child Mind Institute, New York, NY, United States

Recent work revealed that resting-state fMRI (rsfMRI) network dynamics in the mouse brain governed by infraslow transitions between a limited set of recurring BOLD co-activation patterns. Here we extend these findings to the macaque and awake human brain, showing that in both these higher mammalian species rsfMRI timeseries can be similarly deconstructed into a set of oscillatory coactivation patterns, whose occurrence is phase-locked to intrinsic global fMRI Signal (GS) fluctuations. Our results reveal a fundamental, evolutionarily conserved spatiotemporal structure of resting-state fMRI activity.

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