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Abstract #0575

Power and Frequency Fluctuations of Gastric Electrical Activity Modulate fMRI Activity in Rat Brains

Jiayue (Cherry) Cao1, Xiaokai Wang1, Yizhen Zhang2, and Zhongming Liu1,2
1Biomedical Engineering, University of Michigan, ANN ARBOR, MI, United States, 2Electrical Engineering and Computer Science, University of Michigan, ANN ARBOR, MI, United States

The stomach-brain interaction is critical for regulating gastric function. Prior studies suggest that the brain maintains a slow rhythm coupled to the gastric slow wave – a rhythmic activity that paces the stomach. Here, we find a brain network encodes the frequency and power fluctuations of gastric rhythms in the resting state. Rhythmic activity of the stomach primarily engages the NTS-insula-somatosensory network. Dysrhythmic activities, such as bradygastria and tachygastria engage additional regions in the anterior cingulate cortex, prelimbic cortex, and infralimbic cortex. The alternation of dysrhythmic and pace-making activity in the stomach causes activity fluctuations across a central gastric network.

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