Abstract #0578

Inhibitory Thalamic Reticular Nucleus Drives Frequency Specific Brain-wide Responses

Xunda Wang^1,2, Alex T. L. Leong^1,2, Eddie C. Wong^1,2, Teng Ma^1,2,3, Pit Shan Chong⁴, Chi Him Poon⁴, Pek-Lan Khong³, Lee-Wei Lim⁴, and Ed X. Wu^1,2

¹Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China, ²Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China, ³Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China, ⁴School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China

Thalamic inhibition from thalamic reticular nucleus has been shown to provide critical gating upon thalamo-cortical interactions and exert selective modulation on information processing according to behavioral demands. However, where and how thalamic reticular nucleus exerts control of brain-wide neural activities over different spatial and temporal scales remained unclear. In this study, we demonstrate for the first time the frequency specific brain-wide responses driven by inhibitory somatosensory thalamic reticular nucleus using optogenetic fMRI. Such frequency specific engagements of brain-wide neural activities could underlie selective modulation of local circuits versus global networks in different brain functions.

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