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Abstract #0577

Resonant oscillatory modes in rat cortical activity revealed by ultra-fast fMRI

Joana Cabral1,2, Francisca F. Fernandes1, and Noam Shemesh1
1Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal, 2Life and Health Sciences Research Institute, University of Minho, Braga, Portugal

We provide evidence of the oscillatory nature of spontaneous BOLD signal fluctuations by performing a spectral analysis of fMRI signals recorded at unprecedented time resolution (TR = 38 ms) from a frontal brain slice of sedated and anesthetized rats. Oscillations peaking between 0.03 Hz and 0.25 Hz are detected in the cortex under sedation, drastically decreasing in power with deep anaesthesia. Notably, the power of BOLD signal oscillations is modulated in space and time, synchronizing in phase across distant bilateral brain areas, providing insights into the mechanisms underlying resting-state functional connectivity.

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