Skeletal muscle biopsy is the gold-standard in the diagnosis of inflammatory and hereditary muscle disorders. Ten patients who underwent muscle biopsy for diagnostic purposes were examined by qMRI (Fat-fraction, water T2-time and diffusion). The fat fraction, the severity of degenerative and inflammatory parameters and the amount of type 1/2-fibers were determined in all samples. The amount of fat tissue correlated significantly between histopathology and qMRI. EPG Water T2-time correlated with the in the histopathologic analysis. The study provides the basis for qMRI methods in the follow up of patients with neuromuscular disorders, especially in the context of emerging treatment strategies.