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Abstract #0589

Regional Changes in Ventilation Following Bronchodilation in COPD Are Not Associated With Improved Gas Exchange on Xenon-129 MRI

David Mummy1, Erika Coleman2, Ziyi Wang3, Elianna Bier3, Junlan Lu4, Bastiaan Driehuys1,3,4, and Yuh-Chin Huang2
1Radiology, Duke University, Durham, NC, United States, 2Medicine, Duke University, Durham, NC, United States, 3Biomedical Engineering, Duke University, Durham, NC, United States, 4Medical Physics, Duke University, Durham, NC, United States

Hyperpolarized 129Xe MRI images acquired pre/post-bronchodilator treatment in COPD (N=17) provide a new means of evaluating gas evaluating gas exchange in regions of new, existing, and lost ventilation. Here we demonstrate via longitudinal image registration that, despite improvements in FEV1 and regional ventilation following treatment, no changes in region-based measures of 129Xe barrier or RBC signal were observed. This suggests the presence of persistent vascular abnormalities in COPD that are not addressed by bronchodilation.

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