Abstract #0589

Regional Changes in Ventilation Following Bronchodilation in COPD Are Not Associated With Improved Gas Exchange on Xenon-129 MRI

David Mummy¹, Erika Coleman², Ziyi Wang³, Elianna Bier³, Junlan Lu⁴, Bastiaan Driehuys^1,3,4, and Yuh-Chin Huang²

¹Radiology, Duke University, Durham, NC, United States, ²Medicine, Duke University, Durham, NC, United States, ³Biomedical Engineering, Duke University, Durham, NC, United States, ⁴Medical Physics, Duke University, Durham, NC, United States

Hyperpolarized ¹²⁹Xe MRI images acquired pre/post-bronchodilator treatment in COPD (N=17) provide a new means of evaluating gas evaluating gas exchange in regions of new, existing, and lost ventilation. Here we demonstrate via longitudinal image registration that, despite improvements in FEV1 and regional ventilation following treatment, no changes in region-based measures of ¹²⁹Xe barrier or RBC signal were observed. This suggests the presence of persistent vascular abnormalities in COPD that are not addressed by bronchodilation.

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