Abstract #0591

Response of Hyperpolarized 129Xe MRI measures of ventilation and gas-exchange to anti-fibrotic treatment in Idiopathic Pulmonary Fibrosis

Andrew D Hahn¹, Katie J Carey^1,2, Nathan D Sandbo³, Jeff Kammermann¹, Robert V Cadman³, David G Mummy⁴, Mark L Schiebler^1,2, Amy Malik³, and Sean B Fain^1,2,5

¹Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, ²Radiology, University of Wisconsin - Madison, Madison, WI, United States, ³Medicine, University of Wisconsin - Madison, Madison, WI, United States, ⁴Radiology, Duke University, Durham, NC, United States, ⁵Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States

Predicting outcomes and monitoring longitudinal treatment response in IPF is unreliable using currently available clinical biomarkers. We investigate associations between hyperpolarized ¹²⁹Xe MRI biomarkers of ventilation and gas exchange and treatment with anti-fibrotic medication in IPF patients over a 1-year period. Anti-fibrotic treatment was associated with improved ventilation and gas exchange, relative to no anti-fibrotic treatment, after 1 year. Within-patient improvements in gas exchange were significantly larger in patients treated with anti-fibrotic medications. No longitudinal associations were found between anti-fibrotic treatment and spirometry, suggesting the imaging biomarkers may be more useful for monitoring anti-fibrotic treatment response in IPF.

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