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Abstract #0592

Monitoring Patients with Endobronchial Valve Interventions Using a Multifaceted Hyperpolarized Xenon Lung Function Assessment

Hooman Hamedani1, Stephen Kadlecek1, Faraz Amzajerdian1, Ryan Baron1, Kai Ruppert1, Ian Duncan1, Luis Loza1, Tahmina Achekzai1, Maurizio Cereda1, and Rahim R. Rizi2
1University of Pennsylvania, Philadelphia, PA, United States, 2Radiology, University of Pennsylvania, Philadelphia, PA, United States

Here, we present an approach for comprehensively assessing the lung’s response to an intervention. Using our multi-breath approach during tidal breathing, we evaluated whether after a Treatment with Zephyr Endobronchial Valves, ventilation is successfully redistributed to the healthier lung, and whether this shift in ventilation can effectively improve gas exchange in non-targeted lobes. We showed gas exchange was more than doubled in the upper left lobe, exceeding the modest ventilation increase observed after occlusion of the LL lobe, likely indicating dramatically improved Q. Notably, right lung function was also improved, perhaps due to normalized breathing mechanics.

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