Here, we present an approach for comprehensively assessing the lung’s response to an intervention. Using our multi-breath approach during tidal breathing, we evaluated whether after a Treatment with Zephyr Endobronchial Valves, ventilation is successfully redistributed to the healthier lung, and whether this shift in ventilation can effectively improve gas exchange in non-targeted lobes. We showed gas exchange was more than doubled in the upper left lobe, exceeding the modest ventilation increase observed after occlusion of the LL lobe, likely indicating dramatically improved Q. Notably, right lung function was also improved, perhaps due to normalized breathing mechanics.
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