Abstract #0593

Registration on different lung volumes and its influence on ventilation and perfusion parameters derived by phase-resolved functional lung MRI

Filip Klimeš^1,2, Andreas Voskrebenzev^1,2, Lea Behrendt^1,2, Marcel Gutberlet^1,2, Gesa Helen Pöhler^1,2, Till Frederik Kaireit^1,2, Cristian Crisosto^1,2, Frank Wacker^1,2, and Jens Vogel-Claussen^1,2

¹Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, ²Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Centre for Lung Research (DZL), Hannover, Germany

Correction of lung motion is a mandatory step for the voxel-wise signal analysis of Fourier Decomposion (FD) based methods, such as phase-resolved functional lung (PREFUL) MRI. Usually, all images are registered towards one fixed image in intermediate lung position. In this work, a group oriented registration approach with three different target images (expiration, middle, inspiration) was tested and the influence on functional parameters derived by PREFUL was evaluated in 41 study participants. While small significant differences were observed, high absolute agreement of all functional ventilation and perfusion parameters was found indenpedent on the chosen target volume.

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