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Abstract #0614

Accurate and precise myocardial T1 and T2 mapping in a single breath-hold with multi-parametric SASHA

Kelvin Chow1, Genevieve Hayes2, Jacqueline Flewitt2, Patricia Feuchter2, Carmen Lydell2, Andrew Howarth2, Joseph Pagano3, Richard Thompson4, Peter Kellman5, and James White2
1Cardiovascular MR R&D, Siemens Medical Solutions USA, Inc., Chicago, IL, United States, 2Stephenson Cardiac Imaging Centre, University of Calgary, Calgary, AB, Canada, 3Division of Pediatric Cardiology, University of Alberta, Edmonton, AB, Canada, 4Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, 5National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States

A novel multi-parametric cardiac mapping sequence, mSASHA, is proposed to calculate T1 and T2 maps in a single breath-hold. mSASHA is validated against spin-echo in phantoms with -0.7±0.4% T1 error and -1.3±1.3% T2 error. In 10 healthy volunteers at 3T, mSASHA had similar T1 values to SASHA in the myocardium (1523±18 ms vs. 1520±18, p>0.05) and blood pool (2054±61 ms vs. 2060±65 ms, p>0.05). mSASHA had similar myocardial T1 coefficient of variation (CoV) to SASHA and MOLLI and similar myocardial T2 CoV to T2p-bSSFP (p>0.05). mSASHA provides accurate and precise T1 and T2 maps in a single breath-hold.

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