Abstract #0614

Accurate and precise myocardial T1 and T2 mapping in a single breath-hold with multi-parametric SASHA

Kelvin Chow¹, Genevieve Hayes², Jacqueline Flewitt², Patricia Feuchter², Carmen Lydell², Andrew Howarth², Joseph Pagano³, Richard Thompson⁴, Peter Kellman⁵, and James White²

¹Cardiovascular MR R&D, Siemens Medical Solutions USA, Inc., Chicago, IL, United States, ²Stephenson Cardiac Imaging Centre, University of Calgary, Calgary, AB, Canada, ³Division of Pediatric Cardiology, University of Alberta, Edmonton, AB, Canada, ⁴Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, ⁵National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States

A novel multi-parametric cardiac mapping sequence, mSASHA, is proposed to calculate T₁ and T₂ maps in a single breath-hold. mSASHA is validated against spin-echo in phantoms with -0.7±0.4% T₁ error and -1.3±1.3% T₂ error. In 10 healthy volunteers at 3T, mSASHA had similar T₁ values to SASHA in the myocardium (1523±18 ms vs. 1520±18, p>0.05) and blood pool (2054±61 ms vs. 2060±65 ms, p>0.05). mSASHA had similar myocardial T₁ coefficient of variation (CoV) to SASHA and MOLLI and similar myocardial T₂ CoV to T₂p-bSSFP (p>0.05). mSASHA provides accurate and precise T₁ and T₂ maps in a single breath-hold.

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