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Abstract #0631

Simultaneous pure spin-echo and gradient-echo BOLD fMRI using Echo Planar Time-resolved Imaging (EPTI) for mapping laminar fMRI responses

Fuyixue Wang1,2, Zijing Dong1,3, Lawrence L. Wald1,2, Jonathan Polimeni1,2, and Kawin Setsompop4,5
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Harvard-MIT Health Sciences and Technology, MIT, Cambridge, MA, United States, 3Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA, United States, 4Department of Radiology, Stanford University, Stanford, CA, United States, 5Department of Electrical Engineering, Stanford University, Stanford, CA, United States

We introduced a novel imaging approach SE-EPTI to address the T2’-contamination in SE-EPI for higher specificity of BOLD fMRI. EPTI resolves multi-contrast distortion/blurring-free images to simultaneously obtain: a pure SE image with minimal T2’-contamination, multiple GE images with various T2’-weightings, and conventional SE-EPI images with different levels of T2’-contamination. We demonstrated at 7T that the pure SE can significantly reduce the draining-vein-effect, and by using shorter ETLs, less T2’-contamination was introduced. A new echo-train-shifting method is also proposed for SE-EPTI to offer flexibility of achieving shorter TEs, allowing us to examine the TE dependence of the signal contribution.

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