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Abstract #0632

VASO-fMRI with Nordic-PCA for laminar sensory testing at 7 Tesla

Nils Dennis Nothnagel1, Alison Symon1, Andrew Tyler Morgan1,2, Renzo Huber3, John Riddell1, and Jozien Goense1
1Institute of Neuroscience & Psychology, University of Glasgow, Glasgow, United Kingdom, 2NIH, Bethesda, MD, United States, 3Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands

The most commonly used contrasts in laminar fMRI are blood-oxygen-level-dependent (BOLD) and vascular-space-occupancy (VASO). However, at laminar resolution, brain activity is often buried under noise, complicating the detection of small changes in activation.Here, we show the successful extraction of laminar brain activity of a complex-valued BOLD- and VASO-fMRI time series during a somatosensory task using NORDIC-PCA denoising. We expect this method to be a great asset for laminar sensory fMRI experiments as it reduces the need for anatomically informed smoothing or anisotropic filtering, which might be helpful for very small voxel sizes or when small activated areas are studied.

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