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Abstract #0647

Estimation of intra-axonal axial diffusivity by tensor-valued dMRI and powder-averaging

Markus Nilsson1, Samuel St-Jean1,2, Christian Beaulieu2, and Filip Szczepankiewicz1
1Clinical Sciences Lund, Lund University, Lund, Sweden, 2Department of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada

The intra-axonal axial diffusivity (Da) has a prominent role in describing and modeling the white matter microstructure, but cannot be obtained from regular diffusion tensor imaging due to the influence of orientation dispersion and extracellular water. It may be estimated using higher b-values and modeling, however, its estimation is still an ill-posed problem or requires knowledge of the orientation distribution function. Here, we show that using b-tensor encoding and powder averaging turns the problem into a well-posed one and allows rapid mapping across the whole brain yielding Da values of 2.2-2.7 ┬Ám2/ms.

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