Meeting Banner
Abstract #0648

Dynamic Changes in Brain Tissue Strain and ADC over the Cardiac Cycle quantified at 7T MRI

Jacob-Jan Sloots1, Martijn Froeling1, Geert Jan Biessels2, and Jaco Zwanenburg1
1Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 2Neurology, University Medical Center Utrecht, Utrecht, Netherlands

The apparent diffusion coefficient (ADC) in brain tissue slightly varies over the cardiac cycle. In this study, we investigate to what extent ADC variations can be explained by brain tissue strain, which affects the measured MRI signals. To this end, we developed a high-field MRI sequence that simultaneously measures both ADC and tissue strain. Preliminary results in 2 volunteers show that ADC fluctuations over the cardiac cycle are an order of magnitude larger than could be explained from measurement errors induced by tissue strains. Consequently, ADC fluctuations in the brain probably reflect physiology.

This abstract and the presentation materials are available to members only; a login is required.

Join Here